Could This Popular Pain-Killer Be Causing Celiac Disease?

A new study published in the American Journal of Physiology reveals that a popular NSAID drug known as indomethacin may be triggering celiac disease in those who eat gluten-containing foods such as wheat.

Titled, "Gliadin intake alters the small intestinal mucosa in indomethacin-treated HLA-DQ8 transgenic mice," the animal study concluded that the protein gliadin (one of several prolamine proteins in wheat together colloquially known as a 'gluten'), '...in combination with COX inhibition [produced through indomethacin treatment] caused a basal inflammatory status and an oxidative stress condition in the small intestine of DQ8 mice [a celiac disease susceptibility gene], thus triggering the mucosal lesion and, subsequently, an antigen-specific immunity."

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